| Registro completo |
| Provedor de dados: |
BJM
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| País: |
Brazil
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| Título: |
Clinical significance of the isolation of Candidaspecies from hospitalized patients
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| Autores: |
Magalhães,Yankee C.
Bomfim,Maria Rosa Q.
Melônio,Luciane C.
Ribeiro,Patrícia C.S.
Cosme,Lécia M.
Rhoden,Cristianne R.
Marques,Sirlei G.
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| Data: |
2015-03-01
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| Ano: |
2015
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| Palavras-chave: |
Fungal infections
Susceptibility profile
Nosocomial infections
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| Resumo: |
In this study, we isolated and phenotypically identified 108 yeast strains from various clinical specimens collected from 100 hospitalized patients at three tertiary hospitals in São Luís-Maranhão, Brazil, from July to December 2010. The isolates were analyzed for their susceptibility to four of the most widely used antifungal agents in the surveyed hospitals, amphotericin B, fluconazole, 5-flucytosine and voriconazole. The species identified were Candida albicans (41.4%), Candida tropicalis (30.1%), C. glabrata (7.4%), Candida parapsilosis(5.5%), Candida krusei (4.6%), Cryptococcus neoformans (4.6%), Trichosporonspp. (3.7%), Candida norvegensis (0.9%), Rhodotorula glutinis (0.9%) and Pichia farinosa (0.9%). A higher isolation rate was observed in the following clinical specimens: urine (54 isolates; 50%), respiratory tract samples (21 isolates; 19.4%) and blood (20 isolates; 18.6%). Candida albicans isolates were 100% sensitive to all antifungal agents tested, whereas Candida krusei and Crytococcus neoformans displayed intermediate resistance to 5-flucytosine, with Minimal Inhibitory Concentration (MIC) values of 8 mg/mL and 16 mg/mL, respectively. Both strains were also S-DD to fluconazole with an MIC of 16 mg/mL. C. tropicalis was resistant to 5-flucytosine with an MIC of 32 μg/mL. This study demonstrates the importance of identifying the yeast species involved in community and nosocomial infections.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000100117
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| Editor: |
Sociedade Brasileira de Microbiologia
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| Relação: |
10.1590/S1517-838246120120296
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Microbiology v.46 n.1 2015
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| Direitos: |
info:eu-repo/semantics/openAccess
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